Severe acute hepatitis in children of unknown cause has been reported in many countries and regions since March 2022. At present, the etiology of the disease is unknown, and no related cases have been reported in China. To prepare for medical treatment in advance, the NHC has formulated guidelines for the Diagnosis and Treatment of Severe acute Hepatitis in Children of Unknown Cause (Trial).

According to the guidelines, as of May 20, 2022, data from the European Surveillance System show that the disease can be seen in children of all ages, mostly under 5 years old; 14.1% of hospitalized children were in intensive care units. On 27 May 2022, who announced that 33 countries have reported 650 suspected cases, with at least 38 requiring liver transplantation and 9 deaths. Current evidence does not find a significant epidemiological association between the cases and does not support infectious disease.

Guide, unexplained children presented with acute onset of severe acute hepatitis, more show is weak and poor appetite, digestive tract symptoms such as nausea, vomiting, diarrhoea, abdominal pain, accompanied by make color of urine, yellowing of the skin, sclera, some children can have have a bowel movement color white, hepatomegaly, fever and respiratory symptoms, individual can have the spleen. A small number of cases can develop into acute liver failure in a short time, with progressive aggravation of jaundice and hepatic encephalopathy.

If appear unknown reason children how is severe acute hepatitis treated? According to the guidelines, comprehensive treatment measures should be taken, focusing on symptomatic and supportive treatment. Changes in the condition should be closely observed, mental status should be assessed, laboratory indicators should be monitored to prevent complications. Patients with liver failure should be promptly referred to a hospital with treatment capacity.

Prevention and control measures include hand hygiene, wearing masks and eating well, the guidelines said. In clinical work, medical staff should take standard precautions and report suspected cases promptly as required.